Complexes of platelet factor 4 and heparin activate Toll-like receptor 4
نویسندگان
چکیده
منابع مشابه
Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches
Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian po...
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Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether antigenic complexes between polyphosphates and PF4 released from activated platelets might inten...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2015
ISSN: 1538-7933
DOI: 10.1111/jth.12847